Call edition 2012

A new edition of the Prize of the Belgian Development Cooperation has been launched. This call is open until March 31st, 2011. You can read in the regulations whether you comply with the criteria for participation.

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Study of inflammation-associated anaemia in African trypanosomiasis and development of anti-disease and drug-targeting strategies

Benoît STIJLEMANS researcher laureate
bstijlem@vub.ac.be

°1971 Belgium
Ph.D. in Applied Biological Sciences, Vrije Universiteit Brussel, Belgium, 2006

Study of inflammation-associated anaemia in African trypanosomiasis and development of anti-disease and drug-targeting strategies

The work of Benoît Stijlemans represents an important contribution to the understanding of the pathogenic mechanisms in trypanosomiasis through the characterizing of trypanosome molecules involved in the hyperactivation of the immune system and the characterizing of molecular pathways involved in the anaemia associated with the infection. His work also includes an original attempt to combat the disease, based on the neutralization of macrophage hyperactivation and on the developing of specific camel antibodies, these last equally useful for diagnostics. Much of the work has already been published in leading international journals. Its relevance to development lies in the fact that the research relates to one of the neglected – in terms of the WHO – diseases. African trypanosomiasis is a deadly parasitic disease that infects both humans and animals in Africa. The wide distribution of these trypanosomes in local populations, cattle and wild animals, coupled with the lack of lasting measures, mean that African trypanosomiasis continues to be a major health problem. The work is all the more relevant because it may mark a breakthrough in the diagnosis and control of the disease, whose incidence is sharply increasing.
 

Report: Prof. E. Van Marck, University Hospital Antwerp and Department of Morphology, Universiteit Antwerpen, Belgium