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Phytochemical study of two medicinal plants of Cameroon : Garcinia smeathmannii and Garcinia polyantha (Guttiferae)/Evaluation of their biological activity and some chemical transformations

Justin KOMGUEM researcher laureate
komguemjus@yahoo.fr

°1972 Cameroon
Master in Organic Chemistry, 2001

Etudes phytochimiques de deux plantes médicinales du Cameroun: Garcinia Smeathmannii et Garcinia Polyantha (Guttiferacees)/Evaluation de leurs activités biologiques et quelques transformations chimiques

This work can stand any international comparison. It attests to the comparatively higher level of the University of Yaoundé in Cameroon, and to the strong qualities of Mr Komguem. This doctoral thesis describes the phytochemical study and evaluation of the biological activity of the bark of two plant species of the Garcinia genus used in traditional medicine in Cameroon. The plants in question are Garcinia smeathmannii and Garcinia polyantha.
The bibliography has been very thoroughly prepared. The extraction procedures used, the chromatographic purification and isolation of over twenty natural products with diverse chemical structures, point to a thorough physicochemical knowledge and experience. Semisynthesis was used to prepare derivatives of several of these natural substances. The various spectroscopic techniques employed in the structural clarification of all these molecules led to the identification of more than ten new products.
The biological evaluation of both extracts and pure components points among other things to the presence of an antibacterial, antioxydative or antileishmania activity. Moreover, these plants exhibited no acute or chronic toxicity.
The thesis is the result of enormous effort. It is clearly the fruit of a permanent collaboration with institutions in other countries in which knowledge and experience were exchanged. External technical support may have been called on, which of course in no way detracts from its merits, rather the contrary.
The results of this work are perhaps not to be translated immediately into actual applications in the interest of public health; relevance should rather be sought in the high level of scientific potential contained in it. This is undeniably important for the future of Cameroon.
 

Report: Prof. Emeritus J. Totté, Department of Pharmaceutical Sciences, Universiteit Antwerpen, Belgium